Overall, the process involved the down-regulation of transcriptional regulation ... highlighting the potential implications of Kla in cardiac regeneration and aging. Through multi-omics analysis ...

Epigenetic regulation thus enables differences in the cells of the brain, muscles, and skin by silencing and activating genes. Epigenetic changes in gametes have a special role, as they can also ...

The mechanisms underpinning axon ... nerve regeneration. Nerve regeneration is supported by cohesin, which generates long and complex promoter–enhancer loops at regenerative genes. This work shows ...

NcRNAs, including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), are involved in the epigenetic regulation of HSC activation. These ncRNAs can modulate gene expression at ...

Chroma Medicine highlighted data demonstrating the advantages of epigenetic editing for multiplex gene regulation at the American Society of Gene & Cell Therapy (ASGCT) 26 th Annual Meeting in ...

presented data demonstrating the advantages of epigenetic editing for multiplex gene regulation at the American Society of Gene & Cell Therapy 26th Annual Meeting in Los Angeles. Simultaneous ...

A failure to activate these pathways upon injury is underlying a lack of robust axon regeneration in the mature mammalian central nervous system. Epigenetics and epitranscriptomics are key regulatory ...

The mechanisms involve an epigenetic regulation of gene transcription ... (6-10) In this study, in an effort to discover new pharmacological modalities to aid in axon regeneration, we employed ...

We thank Prof. Markus Meister of the California Institute of Technology for providing the code for the looming visual stimulus test. This work was supported in part by a General Research Fund from ...

Building on their past success, researchers used a small molecule called TTK21 to activate genetic programming that induces axon regeneration in neurons. TTK21 changes the epigenetic state of ...