High thymidylate synthase (TS) level in cancer tissue is considered to result in resistance to pemetrexed therapy for advanced stages of nonsquamous non-small cell lung cancers. To further ...

Next, by analyzing colons of mice in which obesity was induced by a high-calorie diet, it was found that colonic inflammation, along with both hepatic ERK pathway activation and increased β-cells ...

One-fifth of patients in a phase 1 study responded to an investigational ERK inhibitor from Merck, bolstering hopes that this type of drug could be used effectively in combination with other ...