The complex interactions between the nervous and immune systems are pivotal in both health and disease, but the cellular and molecular mechanisms underlying ...

Glial cell line derived neurotrophic factor (GDNF) signals through a multicomponent receptor complex consisting of RET receptor tyrosine kinase and a member of GDNF family receptor α (GFRα).

New studies show that astrocytes, long thought to be support cells in the brain, are crucial intermediaries for relaying messages to neurons.

Glial development is the biological process by which glial cells – which comprise most of the non-neuronal cells present in the nervous system and include oligodendrocytes, astrocytes and ...

AskBio's approach meanwhile will involve using an adeno-associated virus (AAV) vector to deliver a gene for human glial cell line-derived neurotrophic factor (GDNF) into the neurons in the putamen.

Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK Correspondence to: Dr M Hadjivassiliou, Department of Neurology, The ...