From basal laminar deposits to foveal centering, a new framework refines what clinicians see—and what they treat—in outer retinal disease, as presented at the 2025 International SPECTRALIS Symposium – ...

Purpose To quantitatively explore preretinal abnormal tissue (PAT) in macula-on rhegmatogenous ... possibly shaping future clinical guidelines for managing patients after retinal detachment surgery.

But in fact, intraretinal scarring, which begins as early as 1 day after retinal detachment, and gets sequentially worse. That intraretinal scarring is fibroblastic glial tissue that proliferates in ...

(3−5) Natural tissue compartments can be mimicked through 3D coculture ... there are marked differences in RPE and retinal glial cells. (21) RPE and Müller cells exhibit different integrin combination ...

Also, the cell type releasing RRF is as yet unknown. The presence of tetrodotoxin (10 μmol/L) did not significantly alter the inhibitory effect of the retinal tissue, which suggests that glial rather ...

Tissue-enriched genes were downregulated in both areas. However, a neuroinflammation signature was induced only in the retina of the animals where the glial activation resembled what was seen in the ...

Abstract: Summary form only given. In the vertebrate eye light must be funnelled through a mangled mass of scattering tissue by Müller cells [1]. In distinction to conventional waveguides, that are ...

The retina is a delicate tissue in the back of the eye that detects ... Citrullination may have many effects on Muller glial cells which are only just being understood. For example, arginine ...

Purpose: Endogenous tissue inhibitor of matrix metalloproteinase-3 (TIMP ... Rat retinas, human retinal microvascular endothelial cells (HRMECs) and human retinal Müller glial cells were studied by ...

Excessive gliosis has the following characteristics in OCT image: (1) a peculiar hyperreflective lesion representing a “peak-like” form; (2) extending from the RPE through the foveal defect and above ...