The Semaglutide peptide has emerged as a compelling subject in biochemical and physiological research due to its potential ...

The results of experiments in mice models were "astounding," said biochemist Suzanne Pfeffer of Stanford University.

More than 90% of patients achieved clinically meaningful weight reduction compared to placebo in a phase 3 trial of ecnoglutide.

A diabetes medication that lowers brain fluid pressure has cut monthly migraine days by more than half, according to a new ...

Semaglutide, a synthetic analog of glucagon-like peptide-1 (GLP-1), has garnered attention for its intriguing properties and potential implications in various r ...

Obesity is a metabolic syndrome worldwide that causes many chronic diseases. Recently, we found an antiobesity effect of flaxseed polysaccharide (FP), but the mechanism remains to be elucidated. In ...

Furthermore, glucagon signaling was identified as the top-ranked signaling pathway affected in the cardiomyocytes associated with HFpEF. Treatment with a glucagon receptor antagonist significantly ...

In addition, PAX6 knockdown augmented cell apoptosis (Fig 1B), decreased GSIS (Fig 1C), and insulin content (Fig 1D). As both insulin and incretin signalings are crucial cellular events for beta cell ...

Guo: The findings indicate that p38α MAPK is a major player in regulating glucose levels, and the p38α-FOXO1 signaling pathway is a potential therapeutic target for the treatment of Type 2 diabetes.

Trilobites How Brains Send a Signal That It’s Time to Vomit In a study of mice, researchers worked out a neural pathway that could help researchers alleviate nausea symptoms from chemotherapy drugs.

A group of researchers from the Helmholtz Munich Institute for Diabetes and Cancer (IDC) and the German Center for Diabetes Research (DZD) have unraveled a new strategy to alter glucagon receptor ...

In this study, we aimed to explore the antidiabetic effects of Lactobacillus rhamnosus LRa05 on glucose metabolism and gut microbiota in type 2 diabetes mellitus (T2DM) mice. Our data indicated that ...