This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

Monocyte-derived macrophages can replace all myeloid cells in the mouse brain, but only fetal-liver monocytes develop a true microglia identity. Monocyte origins shape their profile as brain ...

BACKGROUND: During atherogenesis, macrophages turn into foam cells by engulfing lipids present within the atheroma plaques. The shift of foam cells toward proinflammatory or anti-inflammatory ...

Objective We aimed at investigating the effects of biliary epithelial cell-derived acute phase response protein orosomucoid 2 (ORM2) in shaping monocyte/macrophage response to liver injury. Design ...

BACKGROUND: Circulating monocytes largely contribute to macrophage buildup in atheromata, which is crucial for clearing subendothelial LDLs (low-density lipoproteins) and dead cells; however, the ...

Since human monocytes only circulate for about three days in the body, the researchers assume that the precursor cells of monocytes in the bone marrow also carry the epigenetic markers.

Immune memory plays a critical role in the development of durable antimicrobial immune responses. How precisely mRNA vaccines train innate immune cells to shape protective host defense mechanisms ...

As a control, we generated spheroids with human foreskin keratinocytes (HFKs) and inserted monocytes and T-cells. We first characterized the macrophage surface markers of TAMs derived from tumor ...

Images of tunneling nanotubes. Arrows pointing to the tunneling nanotubes. Credit: Dupont M., Tunneling nanotubes in immune cells, CC BY 4.0, Confocal image of day 13 HIV-1-infected human ...

The authors would need to perform this series of experiments using freshly isolated monocytes, either from mouse or human. The read-out used for macrophage differentiation (adherence to plastic) is ...