The proposed transition state for hypoxanthine-guanine phosphoribosyltransferases (HGPRTs) has been used to design and synthesize powerful inhibitors that contain features of the transition state.

With a new wave of serums claiming to extend our skin cells' lifespan, can these products help us better understand what lies beneath the surface – or is this simply ‘anti-ageing’ 2.0?

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Genome-wide association studies have ...

Visfatin could act as a nicotinamide phosphoribosyltransferase and biosynthesize NMN (nicotinamide mononucleotide) which mediated a proliferative response in VSMC via ERK and p38 MAPK signaling ...

Here, for the first time, we employ a multiscale and hybrid quantum mechanical–molecular mechanical simulation to study the interaction of OH radicals with a guanine-deoxyribose-phosphate DNA ...

It was found that the ECL intensity of luminol could be enhanced at the surface of XOD/HCPE by adding hypoxanthine (HX) to the solution, and there was a linear relationship between the ECL intensity ...

Obstructive sleep apnea (OSA) has been associated with oxidative stress and various cardiovascular consequences, such as increased cardiovascular disease risk. Quantitative real-time PCR is frequently ...