Here, for the first time, we employ a multiscale and hybrid quantum mechanical–molecular mechanical simulation to study the interaction of OH radicals with a guanine-deoxyribose-phosphate DNA ...

aDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, Toronto, ON, Canada The identification of molecular targets and the ...

With a new wave of serums claiming to extend our skin cells' lifespan, can these products help us better understand what lies beneath the surface – or is this simply ‘anti-ageing’ 2.0?

The proposed transition state for hypoxanthine-guanine phosphoribosyltransferases (HGPRTs) has been used to design and synthesize powerful inhibitors that contain features of the transition state.

Abstract: Cyclic adenosine 3’,5’-monophosphate (cAMP) is a versatile secondary messenger that communicates with Guanine Nucleotide Exchange Factor (EPAC) to transfer cellular signaling and regulates ...

Sorbonne Université, Laboratoire de Chimie Théorique, UMR 7616 CNRS, 75005 Paris, France Equipe Structure et Interactions des macromolécules, UR EGP, Centre d’Analyses et de Recherche, Faculté des ...