The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, FcεRI. Crosslinking of FcεRI initiates an intracellular ...

Etokimab (I-Mab Biopharma), which is optimized for common IL-33 gene polymorphisms, has completed patient recruitment in its ...

A breach in the gut immunity and crossreactivity of the IgE antibodies with skin antigens or direct interaction with specific IgE, Fc receptors on Langerhans cells, mast cells, monocytes ...

The function of the various subclasses of IgG molecules is mediated by the family of Fc receptors for IgG (FcγRs). This Review outlines how FcγRs regulate immune responses and the relevance of ...

EA Sports has released the EA FC 25 Cut and Curl Evolution in Ultimate Team, providing gamers with the opportunity to level up their wingers on the virtual pitch.

Once hailed as the future of immuno-oncology, it’s been a tough few months for any remaining fans of anti-TIGIT antibodies.

Dose-dependent, marked reductions in food intake and significant weight loss observed in obese cynomolgus monkeysBMF-650 compared favorably to published data of a leading GLP-1 RA candidateIND ...

Complex allergen sources contain only a limited number of allergens that induce IgE antibodies in more than 50% of the allergic individuals, so-called 'major' allergens. 'Minor' allergens are less ...

Dendritic cells (DCs) are increasingly being explored as cellular vaccines for tumor immunotherapy, since they provide an effective system of antigen presentation both in vitro and in vivo. An ...

Receptor-Mediated HSA rQTY Nanoparticle Uptake and Delivery for Active Tumor Targeting. To reveal the underlying mechanism for the superior antitumor therapeutic performance of HSA rQTY nanoparticles ...

EP4 Receptor Is Essential for Renal CD44+ Cell Activation In Vivo After Low-Salt and Furosemide Treatment To investigate the importance of EP4 receptor in the CD44+ cell activation after salt ...

Compared with the role of the Fc glycosylation, the importance of N-glycans for interaction of IgM, IgEs, or IgAs with their cellular receptors is less understood. (47) An oligomannosidic glycan at a ...