A dual transcription factor activation method enables rapid generation of vascular organoids, accelerating modeling and therapy development.

Induced pluripotent stem cells (iPSCs) are generated from adult cells that have been reprogrammed to pluripotency. However, in vitro cultivation and genetic reprogramming increase genetic instability, ...

Embryonic stem cells and induced pluripotent stem cells are pluripotent stem cells. Pluripotent stem cells can integrate into embryos and contribute to all tissues, including the germline, ...

The spark came in 2006, when Yamanaka Shinya, Takahashi’s colleague at Kyoto University, reprogrammed ordinary skin cells into induced pluripotent stem cells (iPSCs) – capable of morphing into ...

ABSTRACT: Gene editing technology, which allows for precise modifications to an organism’s genome, has emerged as a transformative tool in genetic engineering. This review introduces the fundamental ...

In their manuscript with the title "Integrated transcriptomic analysis of human induced pluripotent stem cell (iPSC)-derived osteogenic differentiation reveals a regulatory role of KLF16", Ru et al.

HSCN1cl10 cells, like the multiclonal HSCN1 cells, expressed the constitutively active Notch1 protein and grew continuously in the combination of factors consisting of 100 ng/ml each of SCF ...

More information: Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids, Developmental Cell (2025). DOI: 10.1016/j.devcel.2025.04.024 . www.cell.com ...

An international team of researchers led by Max Delbrück Center Scientific Director Professor Maike Sander, MD, has for the first time developed an organoid model of human pluripotent stem cell ...

It is highly expressed in glioblastoma multiforme, the most aggressive brain tumor in adults, and in its stem cells [glioblastoma stem cells (GSCs)], which contribute to treatment resistance and tumor ...

(The other company is Cynata, also working with mesenchymal stem cells but induced pluripotent ones called IPSCs.) “Stem cell therapy is a cornerstone of modern medicine,” the company says. “Stem ...