Most biopsies of patients with eczema did show "sparse keratinocyte necrosis." Whether this will become a histologic marker for calcium channel blocker-related eczema remains to be seen.

[1] This detachment (called acantholysis) is due to the presence of IgG antibodies directed against keratinocyte-adhesion glycoproteins, called desmogleins (DSG), which play a critical role in ...