Lysosomes, which are responsible for breaking down and recycling worn-out cell parts, play a key role in helping malignant cells thrive. "Although the lysosomes are an attractive target ...

Here, we describe the isolation and structure determination of proteins in membrane vesicles derived directly from cells. Structures of the ion channel Slo1 from total cell membranes and from cell ...

J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague 18223, Czechia ...

Notably, highly metastatic triple negative breast cancer cells, that are better adapted at balancing elevated proliferation with invasive capacity also exhibit a dependency on lysosomes and ...