Fourteen patients (3.8%) developed MTX-related clinical neurotoxicity. Of 13 patients rechallenged with intrathecal and/or high-dose MTX, 12 did not experience recurrence of neurotoxicity.

Hero Demon's Soul can be given to Blacksmith Ed along with a Claws+8 to create the Large Sword of Searching. Hero Demon's Soul can be traded to Saint Urbain for the miracle Second Chance.