How one of the oldest components of the human immune system can trigger a mysterious and little-understood syndrome.

The Mast Cell Disease Society The Takeaway Advanced systemic mastocytosis is a rare disease that can cause distressing symptoms and contribute to depression, anxiety, and social isolation.

The Mast Cell Disease Society The Takeaway Advanced systemic mastocytosis is a rare disease that can cause distressing symptoms and contribute to depression, anxiety, and social isolation.

Mast cell activation syndrome, or disease (MCAS), is a condition that causes mast cells to release these substances too frequently, resulting in severe allergic reactions. After detecting an ...

For many patients with diverse and seemingly unrelated symptoms, obtaining an accurate diagnosis can take years of specialist visits and inconclusive tests. Mast cell activation syndrome, a ...

Mast cells are therefore a critical therapeutic target, with emerging strategies focusing on reducing mast cell numbers, inhibiting activation pathways, and suppressing degranulation. 1,5 Mast ...

Poster Presentation: Identification of Clonal Mast Cell Disease in Patients with Anaphylaxis or Evidence of Systemic Mast Cell Activation: A Post Hoc Analysis from PROSPECTOR (Abstract 301 ...

Systemic mastocytosis can lead to itchy skin, headaches, and more. Learn the symptoms, diagnosis, and treatments for this condition, which causes a buildup in your body of too many mast cells -- a ...

In a study of 116 patients with systemic mastocytosis (SM), a rare mast cell disease, about 1 in 5 participants progressed to an advanced form of SM, incurring greater healthcare costs along the way.

As the abnormal mast cells accumulate in different parts of the body—such as the skin, gut, bones and other organs—various, potentially debilitating, symptoms may occur.

Briquilimab targets c-Kit to address mast cell diseases. Patients saw substantial reductions in tryptase as early as week 1. 100% of patients with a single 240 mg dose had complete response at week 8.

When mast cells are activated, the packages spill open, releasing compounds that trigger a suite of immune responses. ... skin inflammation and other symptoms of disease were much milder.