A targeted drug therapy has shown potential to reverse cellular damage in Parkinson's disease by regenerating critical brain ...

Stanford researchers discovered that dialing down an overactive enzyme, LRRK2, can regrow lost cellular “antennae” in key ...

Inhibiting an overabundant enzyme saved a key component of a brain signaling pathway that is vital for motor control in a ...

Inhibition of LKKR2 may rescue neurons that are dying due to a type of Parkinson’s disease that is caused by a single genetic mutation.

New research by Sumeda Nandadasa, Ph.D., reveals how a key protein associated with Meckel-Gruber syndrome, nephronophthisis, ...

More information: Yu Xun et al, GPR45 modulates Gα s at primary cilia of the paraventricular hypothalamus to control food intake, Science (2025). DOI: 10.1126/science.adp3989 ...

Cilia are notoriously difficult to study. In brain cells, a single cilium, only tens of microns long, extends from a cell’s surface into a jumble of other cells. Using traditional microscopy ...

It is known that tar from cigarette smoke painted on the skin of a mouse for a third to a half the lifetime of the animal can induce a skin carcinoma. 9 It seems reasonable to assume that a ...

Do you want to use gestures with Edge browser? Then follow this guide to enable mouse gestures in Microsoft Edge on Windows 11/10.

Tiny hairs, or cilia, in a mouse embryo gyrate clockwise, setting up a leftward flow in the surrounding fluid. This fluid flow is then picked up by static cilia, called immotile cilia, located to the ...

Keywords: primary cilia, signaling pathways, ciliogenesis, ciliopathy, ciliary genes Citation: Kim S-E, Nechipurenko I and Christensen ST (2023) Editorial: Signaling by primary cilia in development ...

Primary cilia (PC) are important signaling hubs, and we here explored their role in colonic pathology. In the colon, PC are mostly present on fibroblasts, and exposure of mice to either chemically ...