Distinctive DNA methylation changes characterize the differentiation of myeloid cells and lymphoid cells from their progenitors. DNA demethylation is more predominant during myeloid ...

The differentiation of monocytes is altered in cancer, which results in the unexpected conversion of a large proportion of monocytic myeloid-derived suppressor cells into polymorphonuclear myeloid ...

Single-cell RNA sequencing (scRNA-seq ... reflected both early developmental blocks and lineage-biased differentiation toward myeloid, lymphoid, and erythroid fates. Analysis showed that primitive ...

Erythroid and lymphoid enrichment were unexpected because AML is typically characterized by a differentiation trajectory toward myeloid cells. This made the team curious about the clinical ...

Tissue-specific immune memory has become a central focus in immunology, drawing attention to the distinct roles of tissue-resident memory lymphocytes, their ...

Altering myeloid cell differentiation, proliferation, and recruitment in the TME Functionally blocking immune-suppressive myeloid cells Reprogramming myeloid cells to acquire pro-inflammatory ...

Though AML is a genetically heterogeneous disease, all its subtypes share a common feature: impaired differentiation of myeloid progenitor cells in the bone marrow. This differentiation block ...

Faron Pharma’s bexmarilimab demonstrates immune-activating and drug-sensitizing potential in myeloid malignancies: Turku, Finland Wednesday, May 28, 2025, 16:00 Hrs [IST] Faron ...

AML is an aggressive blood cancer that originates in the bone marrow and is known to impair the differentiation of myeloid cells, which leads to overproduction of immature cells. The condition ...