A comprehensive map of aberrant hematopoiesis in people with acute myeloid leukemia defines specific cell states and ...

Single-cell RNA sequencing (scRNA-seq ... These patterns reflected both early developmental blocks and lineage-biased differentiation toward myeloid, lymphoid, and erythroid fates. Analysis showed ...

"The first thing it tells us is 'Are the cells normal or not?' then, 'Are they lymphoid or myeloid?'" says Michael Andreeff, MD, PhD, professor of medicine in the Department of Leukemia ...

Aggressive blood cancers all originate in the bone marrow, where the research shows cancer cells depend on the ingredient ...

Hematological malignancies may derive from either of the two major blood cell lineages: myeloid and lymphoid cell lines. The myeloid cell line normally produces granulocytes, erythrocytes ...

Innate lymphoid cells (ILC ... to look at nascent bone marrow formation and show that yolk-sac-derived myeloid cells promote haematopoiesis by promoting specification of a VCAM1 + sinusoidal ...

Haematopoietic stem cells are progenitor cells that have the ability to both generate all types of blood cells, including those of the myeloid and lymphoid lineages, and to replace themselves.

Immune infiltration and state of lymphoid and myeloid cells in the TME by detecting key functional molecules, FOXP3, IFNg, CXCL10, and CCL22 combined with cell lineage markers CD4, CD8, CD68, and ...

Researchers have developed a map of normal hematopoietic cell differentiation and used it to examine how aberrant differentiation can lead to #AML, according to results presented by Andy Zeng, PhD, at ...