Notre Dame won at home against Purdue, 27-13 in 2021. That was Purdue's first trip to South Bend since 2012, as the teams met in a Shamrock Series game at Lucas Oil Stadium in Indianapolis in 2014.

Notre Dame at Purdue picks and predictions Prediction. Notre Dame 23, Purdue 19. Moneyline. Notre Dame (-300) is a super risky play going on the road after a major upset last weekend.

Notre Dame and Purdue used to play annually from 1946-2014 but have played only once since then. The Fighting Irish hold a dominant 57-26-2 advantage, including six straight wins.

Notre Dame vs. Purdue Predictions: Irish Defense Returns to Form John Kennedy After a devastating home loss to Northern Illinois last week, Notre Dame heads to West Lafayette to take on Purdue.

SOUTH BEND, Ind. — Nine thoughts on Notre Dame’s 66-7 blowout of Purdue for the nine touchdowns the Irish scored, including three from quarterback Riley Leonard … on the ground: 1. The most ...

Notre Dame and Purdue are set to square off at Ross-Ade Stadium on Saturday, marking the first trip southwest to West Lafayette for the Fighting Irish since 2013. NEWSLETTERS Emailed Daily.