These cells may be identified by their A2B5 + PSA-NCAM-phenotype (positive for the early oligodendrocyte marker A2B5 and negative for the polysialylated neural cell adhesion molecule). We used ...

This knowledge gap motivates the development of effective models to study the role of environmental cues in oligodendrocyte progenitor cell ... mosaic analysis with double markers (MADM) OPC cultures ...

They found that all cortical neuron lines reported negative for expression of oligodendrocyte marker OLIG1 and astrocyte marker GFAP (data not shown). Meanwhile, expression of markers such as BRN2 ...

A specific epigenetic marker, or a chemical modification in DNA that alters gene activity, may explain why adult oligodendrocyte progenitor cells respond differently to therapies aiming to restore ...

NEW YORK, May 7, 2024 /PRNewswire/ -- Myrtelle Inc. ("Myrtelle" or the "Company"), a clinical-stage gene therapy company focused on developing transformative treatments for neurodegenerative diseases, ...

In Figure 5, expression of mature oligodendrocyte markers is reduced in purified oligodendrocytes using equivalent amounts of cDNA to compensate for presumably lower numbers of oligodendrocytes in the ...

or mature OL markers such as CNPase or MBP (Figure S1). Based on these results, the primary oligodendrocyte lineage cells from mixed glial culture used in the current research could be considered as ...

The differentiation of oligodendroglia from oligodendrocyte precursor cells (OPCs ... Finally, it is also the discovery of a very useful marker for remyelinating oligodendrocytes in disease conditions ...

After 5 days of co-culture, the expression of myelin basic protein (MBP), a marker for mature oligodendrocytes, was significantly increased, while the oligodendrocyte precursor marker platelet-derived ...

Neurons are cells in the brain that govern signaling, and therefore are fundamental in sensory perception, emotional response, the regulation of bodily functions such as heart rate, digestion, and ...

Oligodendrocytes in the white matter are expressing Plexin‐A1. Scale bar = 10 μm. B. Immunostainings of Plexin‐A1 and CNP (pan‐oligodendrocyte marker) were conducted on adjacent sections of a human ...

After three weeks, cells of this brain area showed oligodendrocyte progenitor markers (namely PdgfRalpha and NG2) as well as mature oligodendrocyte markers (Mbp and Plp). These findings were ...