ABC transporter; blood–brain barrier; P-glycoprotein; breast cancer resistance protein; neurologic disease; The blood–brain barrier (BBB) is the primary interface between the bloodstream and the ...

The human P-glycoprotein transporter gene (ABCB1), also known as the multidrug resistance 1 gene (MDR1), acts to expel many immunosuppressive drugs to the outside of the cell. Such drugs are often ...

P-glycoprotein (P-gp), a member of the ATP-binding cassette (ABC) family of transporters, plays a crucial role in the development of multi-drug resistance (MDR) in cancer treatment. P-gp actively ...

P-selectin glycoprotein ligand-1 (PSGL-1) is a glycoprotein found on white blood cells and endothelial cells. It binds to P-selectin, which is a member of the selectin family. This family also ...

It also shouldn't be taken with N-acetyl-DL-leucine, N-acetyl-D-leucine, or P-glycoprotein transporter substrates. Developer IntraBio said levacetylleucine is available now.

From the Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn. Background—Although quinidine is known to elevate ...

Abstract. P-glycoprotein (Pgp) is a prototypical ABC transporter of great biological and clinical significance that confers cancer multidrug resistance and mediates the bioavailability and ...

P-glycoprotein (P-gp) is found to be of considerable interest for the design of drugs capable of treating chemoresistant tumors. This transporter is an interesting target for which an efficient ...

They found P-gp expression and function to be significantly higher in the 21d-SMG group compared with 7d-SMG group and CON, highlighting the impacts of long-term microgravity exposure being ...

DALLAS — A team of SMU biological scientists has confirmed that P-glycoprotein (P-gp) has the ability to remove a toxin from the brain that is associated with Alzheimer’s disease.The finding could ...

\\A team of SMU biological scientists has confirmed that P-glycoprotein (P-gp) has the ability to remove a toxin from the brain that is associated with Alzheimer's disease.