In this regard, Paneth cell marker elevation, up-regulation of Fzd5 and EphB2, and elevated Wnt signaling in villus cells were all prevented by elevating dietary calcium and vitamin D 3 in NWD2 (Figs.

This suggests that in IBD, barrier breakdown may be caused by Paneth cell loss. Interestingly, IFNL (Interferon lambda) induces Paneth cell death in mice via MLKL and STAT1 activation . Also, TNF-α ...

Background: Pure squamous cell carcinomas (SCC) of the genitourinary (GU) tract are less responsive to chemotherapy with limited therapeutic options for systemic disease. SCCs account for 2-8% of ...

T. Sato et al., Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469, 415–418 (2011). Crossref. PubMed. Google Scholar. 51. T. Fevr, S. Robine, D. Louvard, J.

Background: Preclinical data indicated that overexpression of TS correlates with reduced sensitivity to P in antifolate- resistant cell lines. A planned subset analysis of a phase 3 trial (Scagliotti ...

The genetic manipulation of Paneth cells, their tracking and depletion depends on a solid Paneth cell specific Cre transgenic line. Here we describe bulk RNAseq-based expression data from pure, sorted ...