The increasing incidence of genetic and rare diseases is a major factor driving revenue growth in the Antisense ...

In a joint initiative between the Universities of Geneva, Lausanne and Bern, and the EPFL the Dubochet Center for Imaging ...

Peptide Nucleic Acid (PNA) Hybridization Assay for Tissue siRNA Quantification. Quantification of antisense strands in tissues was performed using a PNA hybridization assay as described (45). Briefly, ...

Nucleic-acid therapeutics articles from across Nature Portfolio Nucleic acid therapeutics are based on nucleic acids or closely related chemical compounds. They include antisense oligonucleotides ...

Inside our cells, ribosomes—the tireless "protein factories" of life—have just shown off a new skill they haven't used in ...

Scientists at The Wistar Institute have discovered how a key protein from the Epstein-Barr virus (EBV), EBNA-LP, ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

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Peptides come and peptides go, sometimes too fast. These strings of amino acids—the building blocks of life—are of intense ...

The variety of potentially useful dyes or haptenes available for fluorescent nucleic acid hybridization assays is far greater than what can be obtained from commercial sources 1,2. Since this ...

For example, tetrahedral DNA nanostructure (TDN) is known to have remarkable cell- and tissue-penetrating capacity owing to its size and geometry. TDN can be effectively used for the delivery of ...