Research led by scientists from the Institute of Molecular Biology of Barcelona (IBMB) of the CSIC and the Bellvitge ...

Research led by scientists from the Institute of Molecular Biology of Barcelona (IBMB) of the CSIC and the Bellvitge ...

Figure 1. Actin-based internalization mechanisms of large particulate materials. The trigger mechanism (Left) enables internalization in an adhesion-independent manner. Macropinocytosis is a trigger ...

First, BOS promotes macrophage phagocytosis of bacteria by inducing actin remodeling and upregulating bacterial uptake markers. Studies have shown that BOS inhibits SRC phosphorylation, affects actin ...

He hypothesized that TREM2-deficient microglia might ramp up these external digestive mechanisms to compensate for their deficits in phagocytosis. In particular, TREM2-deficient microglia poorly ...

Introduction: The actin cytoskeleton remodels to enable diverse processes essential to immunity, such as cell adhesion, migration and phagocytosis. A panoply of actin-binding proteins regulate these ...

Branched actin networks are self-assembling molecular motors that move biological membranes and drive many important cellular processes, including phagocytosis, endocytosis, and pseudopod protrusion.

This study provides interesting new insights into the roles of mechanical forces generated by actin polymerization and myosin-II contractility in Fc receptor-mediated phagocytosis. The authors ...

Rationale: After myocardial ischemic injury, improper phagocytic clearance of dying cardiac cells and the ensuing lack of inflammation resolution results in adverse cardiac remodeling and dysfunction ...

However, there was an inherent delay to complete phagocytosis and to clear F‐actin from forming phagosomes. Importantly, we were able to demonstrate that, while in mock‐infected macrophages actin ...