TMEM119, which supports microglial homeostasis, falters in amyloidosis mice. The protein promotes phagocytosis of Aβ, but is degraded along with it. Overexpressing TMEM119 stalled memory loss.

The need for an international actin conference with comprehensive topics, where the latest results and research directions are presented, is critical for the community.

Near-infrared photoimmunotherapy (NIR-PIT) is a cancer treatment modality that uses antibody-photoabsorber (IR700) conjugates to destroy specific cells. The reaction between the antibody and ...

Synthetic phagocytosis, the future of the fight against antibiotic resistance IBEC’s Principal Investigator César Rodriguez-Emmenegger has been awarded an ERC Consolidator Grant to develop ...

Not only have researchers identified how a common cellular protein affects aging, but they’ve tweaked the genes that produce it in fruit flies, extending healthy lifespan by 25% to 30%. The ...

Together, these findings imply that Fc-mediated phagocytosis –but not efferocytosis– had a marked impact on actin remodelling and membrane dynamics. Figure 2. Cytoskeletal remodeling is associated ...

Phagocytosis checkpoints promote tumor immune escape by inhibiting phagocytosis by tumor-associated macrophages (TAMs). SLAMF8, which is mainly expressed on the surface of TAMs, may be involved in ...

Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a ...

Introduction: The actin cytoskeleton remodels to enable diverse processes essential to immunity, such as cell adhesion, migration and phagocytosis. A panoply of actin-binding proteins regulate these ...

Actin has several functions in cancer propagation Actin filaments are part of the cell skeleton and essential for stability and motility. They form a network that dynamically builds up and gets ...