The likely mechanism for both increased rigidity of the cardiac chambers leading on to impaired cardiac filling and thus causing diastolic dysfunction as well as prolonged OTc interval is possibly ...

Everyone is encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You can also contact BioXcel Therapeutics, Inc. at 1-833-201 ...

Pfizer Inc. today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of BRAFTOVI® (encorafenib) in combination with cetuximab ...

Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...

The trial excluded persons with the following conditions at baseline: pregnancy; elevated liver enzymes; uncorrectable electrolyte disorders; a QT interval ... and QTcF prolongation) that were ...

CAST trials showed increased sudden death with few antiarrhythmics QT interval prolongation 4–6% 1.5-fold increase Myocardial infarction, hypertension, chronic kidney disease No trials yet Most ...

24-hour Holter tracing showing: A) Macroalternation of the T wave, B) QTc interval of 640ms and a short-long-short sequence generating an episode of polymorphic ventricular tachycardia associated with ...

Background: The prolongation or shortening of heart rate-corrected QT (QTc) predisposes patients to fatal ventricular arrhythmias and sudden cardiac death (SCD), but the association of dynamic change ...

Introduction Prolongation of the QT interval is a risk factor for sudden death. Methadone treatment is a well-recognised cause of QT interval lengthening in adults. The effect of maternal methadone ...

Background and objective: Prolonged QTc interval on admission and a higher risk of death in SARS-CoV-2 patients have been reported. The long-term clinical impact of prolonged QTc interval is unknown.

Main outcome measures Maximal QTc interval prolongation and its relationship to clinical severity, polymorphic ventricular tachycardia and sudden arrhythmic death while on treatment. Conclusions The ...

Sinus tachycardia and prolonged QT intervals (QTc) on baseline electrocardiography ... with adverse events such as death or recurrent hospitalizations (95% confidence interval: 1.11–9.28, p=0.03).