If this doesn’t work well enough to decrease LDL, doctors may increase the dosage to a 420-mg dose (three 140-mg injections) every 2 weeks. Questions about Repatha’s dosage ...

The effects of Repatha were also studied in people who had high LDL and other cholesterol issues, some of whom were taking other cholesterol medicines. The studies lasted 12 to 80 weeks.

For the FOURIER trial, researchers randomly assigned 27,564 patients with atherosclerotic CVD and LDL of 70 mg/dL or more to subcutaneous evolocumab 140 mg every 2 weeks, 420 mg monthly or placebo.

Repatha is available as a 140 mg prefilled syringe, 140 mg prefilled autoinjector, and a 420 mg Pushtronex® system. So, for 420 mg doses, you will have the option of using three 140 mg prefilled ...

I’m new here, but 420 milligrams for biotherapeutic that’s an antibody drug conjugate with a peptide antibody ratio 2:1 seems well in scope for a modern biotherapeutic product.

During 78 weeks of treatment, the time-weighted mean LDL-C level was 36.6 mg/dL in the Repatha arm, which represents a reduction of 59.8 percent, compared with 93.0 mg/dL in the placebo arm. At week ...

Primary hypercholesterolaemia and mixed dyslipidaemia in adults The recommended dose of Repatha is either 140 mg every two weeks or 420 mg once monthly; both doses are clinically equivalent.

Eligible patients with high cholesterol (LDL-C ≥70 mg/dL or non-high-density lipoprotein cholesterol [non-HDL-C] ≥100 mg/dL) and clinically evident ASCVD at more than 1,300 study locations ...

In another study of pediatric patients aged 11-17 years, clinical trial participants with HoFH receiving Repatha 420 mg monthly by subcutaneous injection for 80 weeks had an average 14% reduction in ...

FOURIER randomized 27,564 patients with established ASCVD, additional high risk criteria and LDL-C >70 mg/dL on statin therapy to Repatha (140 mg Q2W or 420 mg once every four weeks (Q4W)) or ...