St John's Wort is a herb which has been proven to be useful in the treatment of mild and moderate depression. In fact, studies show that it is as effective as Prozac, only with far fewer side-effects.

St. John's wort is a very effective inducer of hepatic CYPs, specifically, CYP3A4, CYP2C9, and CYP1A2. Hyperforin has been found to induce CYP3A4 via activation of pregnane X, an orphan nuclear ...