SpaceX’s Starship spacecraft exploded on its test stand late Wednesday, sending a large fireball into the South Texas sky and dealing another major setback to Elon Musk’s company. It was the fourth time the company has lost a Starship spacecraft this year. In three previous test flights, the vehicle came apart or detonated during its flight.

The huge blast enveloped the craft as it stood upright at Starbase, before massive plumes of flames and smoke mushroomed into the night sky, video footage of the incident late Wednesday showed.