Two-photon microscope image of the germinal center inside a lymph node, showing tingible body macrophages (red). [Garvan] During an immune response, a massive number of B cells are made inside the ...

Even its name is a testament to how enigmatic the tingible macrophage has been. Tingible, which means stainable, certainly gives no clues to its functions – but was, at least, one thing that was known ...

For almost 140 years, the origin and behavior of an enigmatic cell type inside lymph nodes, called a tingible body macrophage, has remained a mystery. Now scientists have tracked the cell's ...

For almost 140 years, the origin and behaviour of an enigmatic cell type inside lymph nodes, called a tingible body macrophage, has remained a mystery. Now, for the first time, scientists at the ...

Tingible, which means stainable, certainly gives no clues to its functions – but was, at least, one thing that was known about the cells. Now, scientists at the Garvan Institute of Medical Research ...

More information: Neta Gurwicz et al, Tingible body macrophages arise from lymph node–resident precursors and uptake B cells by dendrites, Journal of Experimental Medicine (2023). DOI: 10.1084 ...

For example, milk fat globule-EGF factor 8 protein (MFGE8; also known as lactadherin) is expressed by tingible body macrophages and binds phosphatidylserine exposed on the surface of apoptotic ...

Embryonic macrophages regulate the number of stem cells. Although they have a similar morphology (external characteristics), these macrophages differ significantly in terms of their function.