When the macrophages’ ability to consume dying cancer cells or Upd3 production was decreased, tumor growth was significantly reduced.

Brain macrophages serve diversified niches in the brain to maintain the organ’s homeostasis, and can play pathogenic roles in age-related brain disease. Hoping to one day replace dysfunctional ...

Macrophages play a central role in the development of atherosclerotic cardiovascular disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease, cerebrovascular disease, and ...

Efficacy of macrophage checkpoint Clever-1 inhibition with bexmarilimab plus azacitidine in myelodysplastic syndrome: Results from the ph1/2 BEXMAB study.

Researchers at National Jewish Health and colleagues have completed the first study comparing lung macrophages in multiple models of lung injury. The research indicates that macrophages previously ...

Specialized bone marrow niches comprising erythroblasts surrounding a central macrophage where erythroid precursors proliferate, differentiate and enucleate. Tingible body macrophages (TBMs).

Early intermittent hyperlipidemia significantly accelerates atherosclerosis by disrupting macrophage function, highlighting the need for early cholesterol management.

Tumor-infiltrating CD163-positive macrophages and clinical outcomes to first-line nivolumab therapy in patients with advanced clear cell renal cell carcinoma (ccRCC) enrolled in the HCRN GU16-260 ...

Besides a unique damage-associated activation state, alpha-synuclein expression created an expansion in the numbers of BAMs. In a mouse model, border-associated macrophages, not microglia, were ...

More information: Neta Gurwicz et al, Tingible body macrophages arise from lymph node–resident precursors and uptake B cells by dendrites, Journal of Experimental Medicine (2023).

Summary: The mysterious workings of tingible body macrophages (TBMs) have been substantially demystified. These TBMs, a subtype of macrophages within our lymph nodes, were found to devour ...

The results indicate its benign nature: the germinal centres show tingible-body macrophages and polyclonal light chain restriction, the mantle zones are composed of both mature and immature B-cells, ...