Using marijuana with common medications, including blood thinners and drugs used to treat cancer and HIV, may cause significant drug interactions and lead to a potentially harmful buildup in the ...

Briefly, two main families of enzymes contributing the drug metabolism in humans are cytochrome P450 (CYP450), which is responsible for phase I reactions, and uridine diphosphate ...

While our understanding of the importance of many of the enzyme families in insect xenobiotic detoxification is mature, the role of UGT enzymes in insect detoxification of potentially harmful ...

Enzymes have also been used to enhance the effect of other therapeutic efforts. For example, uridine diphospho-glucuronosyltransferase (UGT) enzymes are found in the cytosol and are involved in ...

This research also identifies major metabolizing enzymes responsible for the glucuronidation (UGT1A9) and oxidation (CYP2B6) of HSK3486 and characterizes the mechanism of extrahepatic metabolism. The ...

For example, cruciferous vegetables, citrus foods, and bioactive compounds induce UGT enzymes, which aid Phase 2 detox. Animal studies also suggest benefits of other foods and nutrients ...

UGT learns local structure by identifying the local substructures ... We used four publicly available datasets for the graph classification task, including Enzymes, Proteins, NCI1, and NCI9 from ...

Products of natural origin, such as cannabis, are known to have their effect modulated by cytochrome P450 enzymes and uridine diphosphate (UDP) glucuronosyltransferase (UGT). In humans the enzyme ...

Figure 2. The reaction of morphine with glucuronic acid (which the body makes from glucose) is catalyzed by a UGT enzyme. The resulting product, morphine-3-glucuronide, is extremely water-soluble ...

The study demonstrates novel predictive models for AO, FMO, and UGT metabolism, and extends the existing model ... us to successfully expand predictive models of metabolism to new enzymes — a unique ...