Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment & Technology and State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 ...

uridine diphosphate-N-acetylglucosamine; and X5P, xylulose 5-phosphate. Figure 3. Metabolic remodeling and the development of heart failure. Pathological hypertrophy in response to mechanical overload ...

Digging deeper, the team uncovered the mechanism: HYAL1’s breakdown of HA redirects cellular Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), reducing a key modification (O-GlcNAcylation ...