Overlapping moiré lattices in 2D materials yield tunable quantum properties and novel atomic motifs by Seoul National University edited by Sadie Harley, reviewed by Robert Egan Editors' notes ...

Novel RBM39 Degrader Demonstrates Complete Tumor Regression in Mechanism-based Ewing Sarcoma Models RBM39 is an RNA-binding motif protein overexpressed in multiple cancers. Leveraging deep expertise ...

Exploring drug-target binding affinity (DTA) is essential for drug discovery. Numerous works rely on the one-dimensional SMILES representation of drugs for predicting drug-target affinity, but ignore ...

This repository contains the code, computing environment description, and software/package versions for the analysis of transcription factor motifs and binding sites in the human genome. The ...

Rare Merlin and King Arthur text found hidden in binding of medieval book The ‘extremely significant' text was hidden for centuries. By Andrew Paul Published Mar 31, 2025 12:01 PM EDT ...

Background: Pts with VHL disease are at risk of developing malignant tumors such as renal cell carcinoma (RCC) due to VHL gene inactivation, leading to activation of hypoxia-inducible factors (HIFs).

VHL is one of those diseases that you learn about in medical school but rarely see in practice, if ever. The NIH specializes in these “zebras.” ...

The molecule, dubbed SH6, appears to act through a new binding motif on these transcription factor targets, according to a preprint published before peer review (bioRxiv 2024, DOI: 10.1101/2024.01 ...

Motif shareholders received $90 million in upfront consideration comprised of $50 million in cash consideration and $40 million in Organigram common shares (17,233,951 shares priced based on 30 ...

Elgen Therapeutics Inc. has patented new 4-chromanone derivative proteolysis targeting chimera (PROTAC) compounds comprising a von Hippel-Lindau disease tumor suppressor (VHL)-binding moiety coupled ...

Von Hippel-Lindau (VHL) syndrome is a rare, inherited disease that causes the growth of cysts and tumors in various parts of the body. Learn more about VHL syndrome.