Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By ...

When people think of DNA, they usually think of genes, the parts that code for proteins and drive inherited traits. But there ...

Hypoxia-inducible factor-2α (HIF-2α) inhibitor belzutifan in von Hippel-Lindau (VHL) disease–associated neoplasms: 5-year follow-up of the phase 2 LITESPARK-004 study.

Here, we find that cytosolic AK2 degradation is mediated by Inhibitors of Apoptosis (IAPs), a class of E3 ligases that interacts with target proteins by binding to IAP‐binding motifs (IBM). We have ...

Exploring drug-target binding affinity (DTA) is essential for drug discovery. Numerous works rely on the one-dimensional SMILES representation of drugs for predicting drug-target affinity, but ignore ...

Transcription factor motif and binding site analysis This repository contains the code, computing environment description, and software/package versions for the analysis of transcription factor motifs ...

Belzutifan monotherapy in Chinese patients (pts) with von Hippel-Lindau (VHL) disease–associated tumors: Results of LITESPARK-015 study.

Shelby and my mother were soon both diagnosed with von Hippel-Lindau disease (VHL), a rare genetic disorder caused by a mutation in the VHL gene, leading to tumors in the brain, eyes, spine ...

Synopsis RNA modulates transcription factor binding to DNA, though the subsequent effect on transcription remains unclear. The study demonstrates that the binding of transcription factor ERα is ...

Triple-negative breast cancer (TNBC) is associated with poor prognosis because of the lack of effective therapies. Mixed-lineage protein kinase 3 (MLK3) is a protein that is often upregulated in TNBC ...