The p53 protein is a transcription factor that acts as a tumour suppressor by causing growth arrest or apoptosis in response to DNA damage and other forms of cellular stress 1. The activity of p53 ...

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This fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. After major revisions, the evidence ...

Domain organization of p53 isoforms. Overview of the so far described p53 isoforms that are formed by a combination of four N-terminal (TAp53, Δ40p53, Δ133p53 and Δ160p53) and three C-terminal ...

Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired proteasomal function appears to contribute to heart disease. Specific proteasomal degradation mechanisms ...

Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan 48109, United States ...

1Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. *Corresponding Author: Guillermina Lozano, Department of Genetics, The University of Texas MD Anderson ...