Lysine deprivation decreased STAT3 levels in T cells, inhibiting T-cell proliferation and effector function and ultimately promoting tumor progression. Mechanistically, HCC cells outcompeted T cells ...

The response was achieved after the patient's second dose of 250,000,000 gamma delta t-cells, two weeks after treatment began, in total the patient received approximately 500,000,000 gamma delta t ...

Claudin-18 isoform 2 (CLDN18.2) has emerged as a promising therapeutic target in gastric or gastro-oesophageal junction cancer. Satricabtagene autoleucel (satri-cel; also known as CT041), an ...

Tertiary lymphoid structures (TLSs) serve as hubs for immune cell activation and coordination to generate qualitative local immune responses within tumors. However, the effect of TLSs in pancreatic ...

Objective Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in IBDs. We aimed to analyse the in vivo homing of effector (Teff) and regulatory (Treg) T ...

Patra, A., Nag, A., Chakraborty, A. and Bhattacharyya, N. (2022) PA1 Cells Containing a Truncated DNA Polymerase Protein Are More Sensitive to Gamma Radiation. Radiation Oncology Journal, 40, 66-78. .

The study was published as a paper in Nature Medicine, titled “ Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a Phase I trial,” and ...

Kite Pharma’s bicistronic CAR T-cell therapy hit the main goal of a phase 1a trial, with zero dose-limiting toxicities (DLTs) occurring in patients with advanced B-cell lymphoma (BCL).

PURPOSESmall-cell lung cancer (SCLC) is an aggressive malignancy with limited treatments. Delta-like ligand 3 (DLL3) is aberrantly expressed in most SCLC. Tarlatamab (AMG 757), a bispecific T-cell ...