In an opinion article, investigators argue that gene therapies may not achieve their full potential if the innate inflammation in Duchenne muscular dystrophy is not effectively managed.

Analysis of publicly available Single cell sequencing data from murine adrenal glands shows that adrenals do contain a substantial population of macrophages expressing Ptprc (CD45), Adgre1 (F4/80), ...

The mediators released by CSCs, including IL-13, IL-34, and bone activin, can promote macrophage differentiation and invasion, contributing to tumor progression in vivo (49). Additionally, the number ...

Macrophage infiltration at kidney biopsy predicts response to immunosuppression in patients with lupus nephritis, a recent study finds. Inflammatory cell infiltration is commonly seen in kidney ...

CD68, CD163 and HLA-DR are well-established markers for TAMs M1/M2 phenotypes (19 – 22). CD68 + cells represented total macrophages (M total), and CD68 + HLA-DR + CD163 − cells were defined as M1 ...

Macrophage biomarkers CD68 and CD163 correlate with CRC patient survival [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13.

CD68 + macrophages are activated by TNFα and the fragile H-RS cells are regulated by mediators such as Notch1/Jagged1, and by the angiogenic switch, which is controlled by VEGF in conjunction ...

To determine whether global reduction of CD68 (cluster of differentiation) macrophages impacts the development of experimental pulmonary arterial hypertension (PAH) and whether this reduction affects ...