LJI scientists have discovered that T cells may help detect Parkinson's disease years before motor symptoms appear. Your T ...

A neurological tsunami is looming over India as projections reveal a staggering 168% surge in Parkinson's disease (PD) cases ...

Your T cells work hard to fight disease. Unfortunately, "friendly fire" from T cells can sometimes harm the body's healthy ...

Your T cells work hard to fight disease. Unfortunately, "friendly fire" from T cells can sometimes harm the body's healthy ...

PINK1 is the second most commonly mutated gene in autosomal recessive Parkinson's disease (PD). The PINK1 gene encodes a 581 amino acid serine–threonine kinase, which is cleaved at its N ...

First discovered in 2001, the protein PINK1 has been directly linked to Parkinson’s disease.However, until now, scientists had been unable to visualize human PINK1 or understand how it is switched on ...

The idea of using PINK1 as a target for potential drug therapies has long been touted but not yet achieved because the structure of PINK1 and how it attaches to damaged mitochondria were unknown.

He added that now we know what PINK1 proteins really look like and how they act, scientists may have multiple ways of turning it back on, so damaged mitochondria in people who would otherwise have ...

“PINK1 senses this damage and docks to the surface of mitochondria. Once positioned on the mitochondrial surface, PINK1 becomes active and seeks out a small protein known as ubiquitin and marks it.

14 Mar 2025. A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, ...