A form of Parkinson's disease caused by mutations in a gene known as PINK1 has long been labeled rare. But our research shows it's anything but—at least for some populations.

“We also saw, for the first time, how mutations present in people with Parkinson’s disease affect human PINK1.” The proteins that make up the so-called docking site are important pieces of ...

Misbehaving T cells light up long before Parkinson’s symptoms show, zeroing in on vulnerable brain proteins. Their early ...

First discovered more than 20 years ago, PINK1 is a protein directly linked to Parkinson’s disease, but until now, no one has seen what human PINK1 looks like, or how PINK1 attaches to the ...

In particular, PINK1 has been linked to young-onset Parkinson’s Disease, which affects people under the age of 50. Despite the known link, researchers have previously been unable to visualise ...

Link between PINK1 and Parkinson’s Disease One of the hallmarks of Parkinson’s is the death of brain cells. Around 50 million cells die and are replaced in the human body every minute.

Inactivating mutations in human Parkin, a ubiquitin E3 ligase and PINK1, a kinase, genes present a significant population of inherited Parkinson’s disease. About 90,000 people are diagnosed in ...

A new study reveals that T cells mistakenly attack brain cells expressing PINK1, contributing to Parkinson’s disease. The research also highlights a striking sex difference, with men showing a sixfold ...

A progressive neurological disorder affecting 10 million people globally, Parkinson’s can cause disruptive symptoms such as ...

Family-linked cases can result from genetic mutations in a group of genes, including LRRK2, PARK2, PARK7, PINK1 and SNCA, ... Parkinson's disease is diagnosed based on motor symptoms, ...