Genetic mutations occur everyday in our cells, but the vast majority of them are repaired. New research finds DNA repair is not on PAR in HD cells, causing mutations to build up in people with HD.

Huntington’s disease disrupts genetic "traffic lights," keeping genes green when they should be red. These genetic traffic jams may act to speed brain cell aging and faulty traffic cops ...

Hidden twists in the Huntington’s disease gene could shift symptoms by over a decade! Scientists have uncovered rare “genetic dams” that shape when HD begins - sometimes dramatically ...

For many with Huntington’s disease, recognising faces, navigating familiar places, or reading can be difficult. Scientists studied how and when HD affects how the brain processes what we see—crucial ...

On May 5th, PTC Therapeutics released results from their ongoing Phase 2 PIVOT-HD clinical trial for PTC-518, now called votoplam. Excitingly, they announced that this trial met its primary endpoint – ...

Imagine a busy intersection - traffic is carefully orchestrated with different colored lights, telling drivers when to stop and when to go. If a signal turns yellow, drivers know that the light is in ...

In plain language. Written by scientists. For the global HD community.