Mantzoukas was born in Lynn, Massachusetts and raised in Nahant, Massachusetts, and is the oldest child of Cynthia (née Mourousas) and William Mantzoukas, second-generation Greek-Americans. … See more

Mantzoukas first began writing comedy sketches during his junior and senior years of high school for variety shows. He began performing short-form improvisational comedy (improv) as a part of the Otter Nonsense … See more

Mantzoukas was born with an egg allergy and experiences anaphylaxis if ingested. He has cited this allergy as the cause of his hypochondriac tendencies.
He was previously in a relationship with actress … See more